Calcium Carbide: From Elemental Carbon to <scp>Isotope‐Economic</scp> Synthesis of <scp><sup>13</sup>C<sub>2</sub>‐Labeled</scp> Heterocycles<sup>†</sup>
Maria S. Ledovskaya, Vladimir V. Voronin, Nikita R. Valov, Dmitriy E. Samoylenko
Abstract
Comprehensive Summary 13 C‐Carbon is the most available source of carbon‐13. It is a relatively inexpensive solid material, which can be easily converted to calcium carbide‐ 13 C 2 . In current work, Ca 13 C 2 was used for in situ generation of 13 C 2 ‐acetylene in 1,3‐dipolar cycloaddition and [4+2] cycloaddition reaction. For the first time, 1 H ‐1,2,3‐triazoles‐4,5‐ 13 C 2 and isoxazoles‐4,5‐ 13 C 2 were synthesized using calcium carbide‐ 13 C 2 . A Diels‐Alder type cycloaddition of 3,6‐di(pyridin‐2‐yl)‐1,2,4,5‐tetrazine and Ca 13 C 2 was investigated, and the best way for the synthesis of 3,6‐di(pyridin‐2‐yl)pyridazine‐4,5‐ 13 C 2 was proposed for the first time. Here we perform a detailled description of NMR spectra of 13 C 2 ‐labeled triazoles, isoxazoles and 3,6‐di(pyridin‐2‐yl)pyridazine.