Sensitivity Enhancement by Progressive Saturation of the Proton Reservoir: A Solid-State NMR Analogue of Chemical Exchange Saturation Transfer
Michael J. Jaroszewicz, Adam R. Altenhof, Robert W. Schurko, Lucio Frydman
Abstract
H-detected heteronuclear NMR spectra can have their sensitivity enhanced by orders of magnitude in comparison to optimized direct-detect experiments targeting unreceptive nuclei at low natural abundance, using modest hardware requirements and conventional NMR equipment at room temperature.
Topics & Concepts
ChemistryHeteronuclear moleculeSaturation (graph theory)Chemical shiftSpin diffusionNuclear magnetic resonance spectroscopyAnalytical Chemistry (journal)Nuclear magnetic resonanceNMR spectra databaseSolid-state nuclear magnetic resonanceProtonPolarization (electrochemistry)Proton NMRSpectral lineSpectroscopyChemical physicsDiffusionPhysical chemistryChromatographyStereochemistryThermodynamicsCombinatoricsPhysicsMathematicsQuantum mechanicsAstronomyAdvanced NMR Techniques and ApplicationsLanthanide and Transition Metal ComplexesAdvanced MRI Techniques and Applications