Bursty gene expression and mRNA decay pathways orchestrate B cell activation
Yi Zhou, Cornelis Murre
Abstract
mRNA decay rates instruct noisy gene expression that allows a clonal and swift response to invading pathogens whereas in activated B cells increased transcriptional bursting and low mRNA decay rates dictate an activated B lineage gene program.
Topics & Concepts
Gene expressionGeneMessenger RNABiologyCell biologyRegulation of gene expressionGeneticsCellComputational biologyT-cell and B-cell ImmunologyImmune Cell Function and InteractionRNA Research and Splicing