Opposing Roles of <i>SPOP</i> Mutations in Human Prostate and Endometrial Cancers
Ludimila Cavalcante, Sachin Kumar Deshmukh, Jennifer R. Ribeiro, Benedito A. Carneiro, Don S. Dizon, Kartik Angara, Tyler Mattox, Sharon Wu, Joanne Xiu, Phillip Walker, Matthew J. Oberley, Chadi Nabhan, Haojie Huang, Emmanuel S. Antonarakis
Abstract
PURPOSE: mutations in these cancers and explored their association with molecular and immune signatures and patient outcomes. METHODS: values adjusted for multiple comparisons. RESULTS: -mutated tumors and differences in OS were highly dependent on the particular hotspot mutation and histologic subtype. CONCLUSION: mutations drive opposing molecular and immune landscapes in prostate and endometrial cancers-suggesting a loss-of-function mechanism in prostate cancer and gain-of-function mechanism in endometrial cancer-and provide a rationale for tailored therapeutic approaches.