Claudin 5-binding small molecule transiently opens the blood-brain barrier and safely enhances brain drug delivery
Saito Inoue, Keisuke Shirakura, Atsuya Shirono, Jumpei Taguchi, Yoshiki Ikeda, Satomi Tomita, Risa Funatsu, Kosuke Muraoka, Yosuke Hashimoto, Keisuke Tachibana, Nobumasa Hino, Takefumi Doi, Yui Ikemi, Kazuto Nunomura, Bangzhong Lin, Shinsaku Nakagawa, Kazutake Tsujikawa, Shota Tanaka, Masanori Obana, Yasushi Fujio, Takamitsu Hosoya, Hiroyuki Takeda, Masuo Kondoh, Yoshiaki Okada
Topics & Concepts
ClaudinBlood–brain barrierTight junctionChemistrySmall moleculeDrug deliveryPharmacologyCell biologyDrugDrug delivery to the brainDrug discoveryEpilepsyNeuroscienceEndotheliumDrug carrierPermeability (electromagnetism)Targeted drug deliveryMammalian brainCentral nervous systemCancer researchReceptorEvans BlueBarrier Structure and Function StudiesConnexins and lens biologyCaveolin-1 and cellular processes