Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients
Jean Farup, Jesper Just, Frank Vincenzo de Paoli, Lin Lin, Jonas Jensen, Tine Borum Billeskov, Inés Sánchez-Román, Cagla Cömert, Andreas Buch Møller, Luca Madaro, Elena Groppa, Rikard G. Fred, Ulla Kampmann, Lars Christian Gormsen, Steen B. Pedersen, Peter Bross, Tinna Stevnsner, Nikolaj Eldrup, Tune H. Pers, Fábio Rossi, Prem Puri, Niels Jessen
Abstract
proliferation was reduced by in vitro treatment with metformin. Furthermore, metformin treatment reduced FAP content in T2DM patients. These data identify a PDGF-driven conversion of a subpopulation of FAPs as a key event in the fibrosis development in T2DM muscle.
Topics & Concepts
Skeletal muscleAdipogenesisEndocrinologyInternal medicineProgenitor cellMetforminExtracellular matrixBiologyFibrosisPlatelet-derived growth factor receptorGrowth factorCancer researchCell biologyMedicineStem cellDiabetes mellitusAdipose tissueReceptorAdipose Tissue and MetabolismCancer, Hypoxia, and MetabolismMuscle Physiology and Disorders