Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis
Zhe Chen, Lei Li, Weiru Wu, Zhilong Liu, Yongxiu Huang, Li Yang, Qing Luo, Jieping Chen, Yu Hou, Guanbin Song
Abstract
: The findings of our study show that exercise protects proliferative SCs against exhaustion via the Igfbp7-Akt-mTOR axis. These findings establish a link between mechanical signaling, mitochondrial metabolism, epigenetic modification, and stem cell fate decisions; thus, present potential therapeutic targets for muscle diseases correlated with SC exhaustion.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BSatelliteChemistryMedicineCell biologyInternal medicineBiologySignal transductionPhysicsAstronomyMuscle Physiology and DisordersExercise and Physiological ResponsesSpaceflight effects on biology