Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches
Rhoda Oyeladun Oyewole, Abel Kolawole Oyebamiji, Banjo Semire
Abstract
gave 0.950, 0.970 and 0.844 respectively) revealed a very good fitness. Molecular docking studies revealed the hydrogen bonding with the amino acid residues in the binding site, as well as ligand conformations which are essential feature for ligand-receptor interactions. Therefore, the methods used in this study are veritable tools that can be employed in pharmacological and medicinal chemistry researches in designing better drugs with improve potency.
Topics & Concepts
PyrimidineQuantitative structure–activity relationshipDocking (animal)Cancer cell linesChemistryComputational chemistryCombinatorial chemistryStereochemistryTriazoleCancerComputational biologyOrganic chemistryCancer cellBiologyMedicineGeneticsNursingSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Biological Evaluation