Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion

Shenxin Zeng, Ming Zeng, Shuai Yuan, Liuxun He, Yuyuan Jin, Jiandong Huang, M Zhang, Menghan yang, Youlu Pan, Zunyuan Wang, Yinqiao chen, Xiangwei Xu, Wenhai Huang, Wenhai Huang