Mucosal Bacteria Modulate Candida albicans Virulence in Oropharyngeal Candidiasis
Martinna Bertolini, Roberto Vázquez-Muñoz, Linda Archambault, Shrey Shah, João Gabriel Silva Souza, Raphael Cavalcante Costa, Angela Thompson, Yanjiao Zhou, Takanori Sobue, Anna Dongari‐Bagtzoglou
Abstract
By comparing Candida albicans virulence and the mucosal bacterial composition in a mouse oral infection model, we were able to dissect the effects of the host environment (immunosuppression), infection with C. albicans , and local modulating factors (availability of sucrose as a carbon source) on the mucosal bacterial microbiome and its role on fungal virulence. We showed that changes in endogenous microbial communities in response to sucrose can lead to attenuation of fungal disease.
Topics & Concepts
VirulenceMicrobiologyCandida albicansMicrobiomeCorpus albicansBiologyBacteriaGeneGeneticsBioinformaticsBiochemistryOral microbiology and periodontitis researchAntifungal resistance and susceptibilityGut microbiota and health