Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host Cells
Xuwen Gao, Xiaobo Sun, Xin Yao, Yixin Wang, Yuan Li, Xiaoxia Jiang, Yanyan Han, Linhan Zhong, Lı Wang, Houhui Song, Yigang Xu
Abstract
displayed antiviral function by positively regulating the MAPK8/JNK1 pathway to promote cell apoptosis. Our data provided evidence that host lncRNAs regulate the innate immune response to BVDV infection.
Topics & Concepts
BiologyVirologyViral replicationGene knockdownVirusSmall interfering RNADownregulation and upregulationInnate immune systemApoptosisRNAImmune systemImmunologyGeneGeneticsCancer-related molecular mechanisms researchAnimal Disease Management and EpidemiologyPlant and Fungal Interactions Research