Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery
Silvia Maria Grazia Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri, M Zara
Abstract
Platelets are classically recognized for their important role in hemostasis and thrombosis but they are also involved in many other physiological and pathophysiological processes, including infection. Platelets are among the first cells recruited to sites of inflammation and infection and they exert their antimicrobial response actively cooperating with the immune system. This review aims to summarize the current knowledge on platelet receptor interaction with different types of pathogens and the consequent modulations of innate and adaptive immune responses.
Topics & Concepts
PlateletHemostasisImmune systemImmunologyInnate immune systemInflammationBiologyThrombosisPlatelet activationReceptorMedicineInternal medicineGeneticsPlatelet Disorders and TreatmentsNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disorders