Synthesis, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, and molecular docking studies of a novel compound based on combination of flurbiprofen and isoniazide
Amina Asghar, Muhammad Yousuf, Ghulam Fareed, Rabia Nazir, Abida Hassan, Aneela Maalik, Tayyaba Nооr, Naseem Iqbal, Lubna Rasheed
Abstract
A novel compound (<bold>1</bold>) shows ∼2.5 and ∼1.7 times enhanced AChE inhibition activity and BuChE inhibition activity respectively compared to flurbiprofen and standard drug (<italic>i.e.</italic>physostigmine). It has also been confirmed by comparative AutoDock studies.
Topics & Concepts
ButyrylcholinesteraseFlurbiprofenChemistryAcetylcholinesteraseAchéDocking (animal)AutoDockPhysostigmineStereochemistryIn vivoCholinesterasePharmacologyEnzymeBiochemistryAcetylcholineGeneBiotechnologyBiologyIn silicoMedicineNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsEnzyme function and inhibition