miR-137: A Novel Therapeutic Target for Human Glioma
Yajun Wang, Riling Chen, Xia Zhou, Runmin Guo, Jingwen Yin, You Li, Guoda Ma
Abstract
MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.
Topics & Concepts
GliomaNeuroscienceComputer scienceMedicineCancer researchBiologyMicroRNA in disease regulationCircular RNAs in diseasesExtracellular vesicles in disease