Electrochemical Oxidative Regioselective C–H Cyanation of Imidazo[1,2-<i>a</i>]pyridines
Ting Cui, Yanling Zhan, Changhui Dai, Jun Lin, Ping Liu, Peipei Sun
Abstract
Electrochemical oxidative regioselective C–H cyanation of imidazo[1,2-a]pyridines was developed using readily available TMSCN as the cyano source. The KH2PO4/K2HPO4 buffer was essential for this transformation. This protocol was compatible with a broad range of substituted imidazo[1,2-a]pyridines and provided the C3 cyanated products in moderate to excellent yields.
Topics & Concepts
CyanationRegioselectivityChemistryOxidative phosphorylationElectrochemistryCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisBiochemistryElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsOxidative Organic Chemistry Reactions