On the Move-Sensitive Fluorescent Aptassay on Board Catalytic Micromotors for the Determination of Interleukin-6 in Ultra-Low Serum Volumes for Neonatal Sepsis Diagnostics
José Gordón, Luis Arruza, María Ibáñez-Vea, María Moreno‐Guzmán, Miguel Ángel López, Alberto Escarpa
Abstract
) in ultralow volumes of diagnostic clinical samples (2 μL). A high agreement between IL-6 levels obtained from our MM-based approach and the method used by the Hospital was obtained (relative error < 3%). The MM-based aptassay is competitive in comparison with that of the Hospital, in terms of a significant reduction of the sample volume (15 times less) and enhanced sensitivity, employing similar analysis times. These results position MM technology with enough potential to achieve high sensitivities in low sample volumes, opening new avenues in diagnosis based on low sample volumes.
Topics & Concepts
SepsisAptamerFluorescenceNeonatal sepsisGrapheneGestational ageGastroenterologyMedicineChemistryMaterials scienceBiomedical engineeringMolecular biologyImmunologyNanotechnologyBiologyPregnancyGeneticsPhysicsQuantum mechanicsNeonatal and Maternal InfectionsAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection