Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection
C. N. Jondle, K. E. Johnson, C. A. Aurubin, P. A. Sylvester, Gang Xin, Weiguo Cui, Anna R. Huppler, Vera L. Tarakanova
Abstract
Gammaherpesviruses establish lifelong infections in a majority of humans and are associated with B cell lymphomas. IL-17A is a host cytokine that plays a well-established role in the clearance of bacterial and fungal infections; however, the role of IL-17A in viral infections is poorly understood. In this study, we show that IL-17A signaling promoted the establishment of chronic gammaherpesvirus infection following the mucosal route of infection, viral lytic replication, and reactivation from latency. Thus, our study unveils a novel proviral role of IL-17A signaling in gammaherpesvirus infection.
Topics & Concepts
Host (biology)VirologyMicrobiologyImmunologyBiologyGeneticsCytomegalovirus and herpesvirus researchPsoriasis: Treatment and PathogenesisInflammasome and immune disorders