Iridium-Catalyzed Enantioselective Allylic Substitution of Vinylcyclopropanes by Carboxylic Acids
Amit Singh Adhikari, Soumen Pandit, Ruchir Kant, Nilanjana Majumdar
Abstract
An efficient method for a highly regio- and enantioselective allylic substitution of vinylcyclopropanes using carboxylic acids as oxygen nucleophile via iridium catalysis has been developed. This represents a highly atom-economic approach for the synthesis of synthetically useful chiral building blocks in high yields. The practical utility of this method is demonstrated by the application of the products in useful transformations.
Topics & Concepts
Enantioselective synthesisAllylic rearrangementIridiumCatalysisChemistryNucleophileCombinatorial chemistrySubstitution (logic)Substitution reactionOrganic chemistryComputer scienceProgramming languageCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis