Inhibition of central activation of the diaphragm: a mechanism of weaning failure
Franco Laghi, Hameeda Shaikh, Stephen W. Littleton, Daniel Morales‐Cano, Amal Jubran, Martin J. Tobin
Abstract
Research into pathophysiology of failure to wean from mechanical ventilation has excluded several factors, including contractile fatigue, but the precise mechanism remains unknown. We recorded transdiaphragmatic pressure and diaphragmatic electrical activity in patients undergoing a T-tube trial. Diaphragmatic recruitment was submaximal at the end of a failed trial despite concurrent respiratory distress, signifying that inhibition of central neural output to the diaphragm is an important mechanism of weaning failure.
Topics & Concepts
Diaphragm (acoustics)MedicineDiaphragmatic breathingRespiratory distressMechanical ventilationWeaningAnesthesiaPathophysiologyMechanism (biology)Respiratory failureVentilation (architecture)Internal medicinePathologyEpistemologyPhysicsLoudspeakerPhilosophyAlternative medicineAcousticsMechanical engineeringEngineeringRespiratory Support and MechanismsNeuroscience of respiration and sleepIntensive Care Unit Cognitive Disorders