Hierarchically tumor-activated nanoCRISPR-Cas13a facilitates efficient microRNA disruption for multi-pathway-mediated tumor suppression
Xiaowei Liu, Suleixin Yang, Li Wang, Xinyue Wu, Xinxin Wang, Chunqing Ou, Jin Yang, Linjiang Song, Shiyao Zhou, Qinjie Wu, Changyang Gong
Abstract
Treatment with CHAIN in hepatocellular carcinoma mouse model achieved significant inhibition of miR-21 expression and rescued multi-pathway, which triggered substantial tumor growth suppression. By efficient CRISPR-Cas13a induced interference of one oncogenic microRNA, the CHAIN platform exerted promising capabilities in cancer treatment.
Topics & Concepts
Gene knockdownmicroRNACancer researchSmall hairpin RNARNA interferenceOncomirHEK 293 cellsCRISPRTransfectionChemistryCell biologyBiologyRNAGeneBiochemistryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesCRISPR and Genetic Engineering