Ultrasound-triggered <i>in situ</i> gelation with ROS-controlled drug release for cartilage repair
Shunli Wu, Hao Zhang, Sicheng Wang, Jinru Sun, Yan Hu, Han Liu, Jinlong Liu, Xiao Chen, Fengjin Zhou, Long Bai, Xiuhui Wang, Jiacan Su
Abstract
A novel strategy to prepare an in situ nanocomposite FLPKT hydrogel is proposed, in which ultrasound-triggered in situ gelation using ROS is a regulatory mechanism. Moreover, ROS generation and KGN release effectively improved cartilage regeneration.
Topics & Concepts
ChondrogenesisCartilageRegeneration (biology)ThrombinChondrocyteBiomedical engineeringIn situCell biologyMaterials scienceFibrinReactive oxygen speciesBiophysicsChemistryPlateletAnatomyImmunologyMedicineBiologyOrganic chemistryOsteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchPeriodontal Regeneration and Treatments