AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization
Xiaoqi Yang, Haoran Liu, Tao Ye, Chen Duan, Peng Lv, Xiaoliang Wu, Jianhe Liu, Kehua Jiang, Hongyan Lu, Huan Yang, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Abstract
Our results indicated that AhR activation could diminish M1 macrophage polarization and promote M2 macrophage polarization to suppress CaOx nephrocalcinosis via the AhR-miR-142a-IRF1/HIF-1α pathway.
Topics & Concepts
Macrophage polarizationChemistryNephrocalcinosisChromatin immunoprecipitationMolecular biologyCell biologyCancer researchKidneyBiologyMacrophageEndocrinologyBiochemistryGene expressionIn vitroGenePromoterPancreatitis Pathology and TreatmentHeme Oxygenase-1 and Carbon MonoxideAlcohol Consumption and Health Effects