Nanoengineered myogenic scaffolds for skeletal muscle tissue engineering
Jacob Quint, Mohamadmahdi Samandari, Laleh Abbasi, Evelyn Carolina Mollocana Lara, Chiara Rinoldi, Azadeh Mostafavi, Ali Tamayol
Abstract
nanoclays (NCs). Physiologically relevant levels of IGF-1 were maintained during a controlled release over two weeks. The NC was able to retain 50% of the released IGF-1 within the hydrogel niche, significantly improving cellular proliferation and differentiation compared to control hydrogels. IGF-1 supplemented medium controls required 44% more IGF-1 than the comparable NC hydrogel composites. The nanofunctionalized scaffold is a viable option for the treatment of extreme muscle injuries and offers scalable benefits for translational interventions and the growing field of clean meat production.
Topics & Concepts
Skeletal muscleTissue engineeringBiomedical engineeringMaterials scienceAnatomyNanotechnologyEngineeringMedicineElectrospun Nanofibers in Biomedical ApplicationsBone Tissue Engineering Materials3D Printing in Biomedical Research