Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults
Lin Chen, Anja Soldan, Andréia V. Faria, Marilyn Albert, Peter C.M. van Zijl, Xu Li, for the BIOCARD Study Team, Marilyn Albert, Anja Soldan, Corinne Pettigrew, Gregory M. Pontone, Leonie Farrington, Corey Demsky, Nicole Johnson, Maura A. Grega, Gay Rudow, Scott Rudow, Michael I. Miller, Susumu Mori, J. Tilak Ratnanather, Andréia V. Faria, Anthony Kolasny, Kenichi Oishi, Laurent Younès, Hanzhang Lu, Peter C.M. van Zijl, Abhay Moghekar, Alexandria Lewis, Anny Zheng, Sara Ho, Ann‐Margret Ervin, David Shade, Jennifer Jones, Hamadou Coulibaly, Mei-Cheng Wang, Yuxin Zhu, Jiangxia Wang, Juan C. Troncoso, David W. Nauen, Javier Redding‐Ochoa, Robert Knox, Paul F. Worley, Jeremy Walston, Mei-Cheng Wang, Yifei Sun
Abstract
Tissue magnetic susceptibility elevations measured at MRI in the entorhinal cortex and putamen were significant predictors of onset of mild cognitive impairment and cognitive decline in cognitively unimpaired older adults, especially those with amyloid neuropathologic abnormalities.