Discovery of novel NF-кB inhibitor based on scaffold hopping: 1,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine
Yue Sun, Zhongfei Gao, Wei-Bin Yan, Bin-Rong Yao, Wenyu Xin, Chunhua Wang, Qingguo Meng, Gui‐Ge Hou
Topics & Concepts
ChemistryApoptosisNF-κBPhosphorylationp38 mitogen-activated protein kinasesInflammationSignal transductionMAPK/ERK pathwayPyrimidineProtein kinase BDocking (animal)IκBαPharmacologyBiochemistryBiologyImmunologyNursingMedicineNF-κB Signaling PathwaysSynthesis and biological activityCytokine Signaling Pathways and Interactions