Copper-enriched diamond-like carbon coatings promote regeneration at the bone–implant interface
Peiman Brouki Milan, Sara Khamseh, Payam Zarrintaj, Bahram Ramezanzadeh, Michaël Badawi, Sophie Morisset, Henri Vahabi, Mohammad Reza Saeb, Masoud Mozafari
Abstract
ratio. Furthermore, Cu/a-C:H thin coating with higher Cu contents showed better antibacterial properties and higher angiogenesis and osteogenesis activities. The coated samples inhibited the growth of bacteria as compared to the uncoated sample (p < 0.05). In addition, such coating composition can stimulate angiogenesis, osteogenesis and control host response, thereby increasing the success rate of implants. Moreover, Cu/a-C:H thin films encouraged development of blood vessels on the surface of titanium alloy when the density of grown blood vessels was increased with enhancing the Cu amount of the films. It is speculated that such coating can be a promising candidate for enhancing the osseointegration features.