Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma
Patrizia Mondello, Stephen M. Ansell, Grzegorz S. Nowakowski
Abstract
Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also discuss precision therapy strategies to reverse their aberrant signaling by targeting mutated proteins or counterbalance epigenetic mechanisms.
Topics & Concepts
EpigeneticsReprogrammingTumor microenvironmentChromatinCancer researchCrosstalkBiologyLymphomaImmune systemEpigenesisEpigenetic therapyDNA methylationTumor cellsCellImmunologyGeneticsGeneGene expressionOpticsPhysicsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsEpigenetics and DNA Methylation