Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses
Ivan Shevchenko, Andreas Mathes, Christopher Groth, Svetlana Karakhanova, Verena Müller, Jochen Utikal, Jens Werner, Alexandr V. Bazhin, Viktor Umansky
Abstract
regulatory T cells and better overall survival of melanoma patients. Tumor-derived soluble factors (in particular, TGF-β) significantly enhanced the frequencies of ectonucleotidase-expressing cells in mice. Our findings suggest that the upregulation of ectonucleotidase expression in T cells promotes extracellular adenosine accumulation and represents an important mechanism of homeostatic immune auto-regulation, which could be hijacked by tumors to evade anti-cancer immunity. Targeting CD39 and CD73 can open new avenues for cancer immunotherapy.
Topics & Concepts
Cancer researchImmune systemTumor microenvironmentCytotoxic T cellPancreatic cancerCD8BiologyT cellCancerImmunologyIn vitroBiochemistryGeneticsAdenosine and Purinergic SignalingCancer Immunotherapy and BiomarkersCAR-T cell therapy research