Adipose tissue macrophage in obesity-associated metabolic diseases
Jingfei Yao, Dongmei Wu, Yifu Qiu
Abstract
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as the crosstalk between ATM and adipocyte in thermogenesis, obesity, insulin resistance and adipose tissue fibrosis have been reviewed. A better understanding of how ATM regulates adipose tissue remodeling may provide novel therapeutic strategies against obesity and associated metabolic diseases.
Topics & Concepts
Adipose tissueInsulin resistanceMacrophage polarizationObesityAdipocyteCrosstalkFibrosisMedicineAdipose tissue macrophagesMacrophageThermogenesisEndocrinologyInternal medicineBioinformaticsBiologyCancer researchOpticsPhysicsBiochemistryIn vitroAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismImmune cells in cancer