SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation
Jilin Wu, Ming Huang, Wentao Dong, Yuelong Chen, Qianghua Zhou, Qiang Zhang, Junjiong Zheng, Yeqing Liu, Yangjie Zhang, Sen Liu, Chenwei Yang, Siting Chen, Jian Huang, Tianxin Lin, Xu Chen
Abstract
assays revealed that MUL1 inhibits the metastasis and proliferation of BCa cells. Overall, our study reveals a novel function and molecular mechanism of SUMO E3 ligases in LN metastasis.
Topics & Concepts
BiologyCancer researchUbiquitin ligaseCell biologyGeneticsUbiquitinGeneUbiquitin and proteasome pathwaysBladder and Urothelial Cancer TreatmentsHistone Deacetylase Inhibitors Research