RMD86, a thiophene derivative, promotes antinociceptive and antipyretic activities in mice
Ryldene Marques Duarte da Cruz, Renan Marinho Braga, Humberto Hugo Nunes de Andrade, Álefe Brito Monteiro, Isadora Silva Luna, Rayssa Marques Duarte da Cruz, Luciana Scotti, Francisco Jaime Bezerra Mendonça, Reinaldo Nóbrega de Almeida
Abstract
presents a greater number of interactions and lower energy values than both the co-crystallized ligand and the reference drug (meloxicam) against COX-1 and COX-2 isoenzymes. The results give evidence of the analgesic and antipyretic properties like NSAIDs suggesting its potential for pain therapy.
Topics & Concepts
AntipyreticAnalgesicPharmacologyContext (archaeology)LickingNociceptionMedicineChemistryInternal medicineReceptorBiologyPaleontologyPain Mechanisms and TreatmentsPharmacological Receptor Mechanisms and EffectsPharmacological Effects of Natural Compounds