Pulmonary delivery of curcumin-loaded glycyrrhizic acid nanoparticles for anti-inflammatory therapy
Chunxian Piao, Chuanyu Zhuang, Minji Kang, Jihun Oh, Minhyung Lee
Abstract
therapeutic effects of GA-Cur were evaluated in ALI mouse models. GA-Cur was administered into the animals by intratracheal instillation. The results showed that GA-Cur reduced pro-inflammatory cytokines in a dose-dependent manner and did so more efficiently than GA, Cur, or GA + Cur. Furthermore, the hemolysis and infiltration of monocytes into the lungs were more effectively inhibited by GA-Cur than the other treatments. The data indicate that GA is an efficient carrier of Cur and an anti-inflammatory drug. Owing to their delivery efficiency and safety, GA-Cur nanoparticles will be useful for treatment of ALI.
Topics & Concepts
CurcuminChemistryPharmacologyIn vivoBioavailabilityIn vitroProinflammatory cytokineInflammationBiochemistryImmunologyMedicineBiologyBiotechnologyPharmacological Effects of Natural CompoundsCurcumin's Biomedical ApplicationsPhytochemistry and biological activity of medicinal plants