Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation
Chunfang Wei, XU Ya, Qian Shen, Rong Li, Xiaoyun Xiao, Phei Er Saw, Xiaoding Xu
Abstract
regulation of lncRNA expression and cancer therapy. In this review, we introduce the subcellular localization and regulatory mechanisms of various functional lncRNAs in cancer and systemically summarize the recent development of NP-mediated nucleic acid delivery for targeted regulation of lncRNA expression and effective cancer therapy.
Topics & Concepts
Subcellular localizationCoding (social sciences)Long non-coding RNACell biologyComputational biologyCancer researchComputer scienceRNABiologyGeneGeneticsSociologyCytoplasmSocial scienceCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancer