Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons
Dmitry B. Zorov, Nadezda V. Andrianova, Valentina A. Babenko, Irina B. Pevzner, Vasily A. Popkov, Savva D. Zorov, Ljubava D. Zorova, Egor Y. Plotnikov, Г. Т. Сухих, Д. Н. Силачев
Abstract
There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice.
Topics & Concepts
Oxidative phosphorylationMitochondrionNeuroprotectionUncoupling AgentsMembrane potentialNeuroscienceCell biologyChemistryBiologyBiochemistryMitochondrial Function and PathologyAdipose Tissue and MetabolismATP Synthase and ATPases Research