Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis
Anh Q. Vo, Gerd Kutz, Herman He, Sagar Narala, Suresh Bandari, Michael A. Repka
Topics & Concepts
PelletsPelletExtrusionFactorial experimentParticle sizePiroxicamDosage formMaterials scienceProcess analytical technologyDissolutionChromatographyResponse surface methodologyKetoprofenPharmaceutical manufacturingDesign of experimentsImmediate releaseStearic acidChemistryChemical engineeringComposite materialMathematicsOrganic chemistryPharmacologyMedicinePhysical chemistryPathologyStatisticsEngineeringBioprocessAlternative medicineDrug Solubulity and Delivery SystemsProtein purification and stabilityAnalytical Chemistry and Chromatography