Free Radical-Promoted Monochloroalkylarylation of Alkenes with Chloralkanes
Yingming Ren, Yaxin Ge, Qinqin Yan, Shiliu Chen, Yang Li, Li‐Jun Li, Zhong‐Quan Liu, Zejiang Li
Abstract
Free radical-initiated cascade cyclization of unactivated alkenes with chloralkanes, which undergoes selective activation of the α-C(sp3)–H bond of chloralkanes, provides a protocol for the synthesis of chlorinated heterocycles or polycyclic compounds. A series of radical inhibition experiments, radical capture operations, and radical clock tests were studied in this system.
Topics & Concepts
ChemistryRadical cyclizationFree-radical reactionFree-radical additionCascadeRadical initiatorRadicalMedicinal chemistryOrganic chemistryCombinatorial chemistryPhotochemistryChromatographyPolymerizationPolymerVanadium and Halogenation ChemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods