Copper‐Curcumin‐Bipyridine Dicarboxylate Complexes as Anticancer Candidates
Fatemeh Emami, Mehdi Aliomrani, Shahram Tangestaninejad, Hossein Kazemian, Mohammadmahdi Moradi, Mahboubeh Rostami
Abstract
Abstract In this study, copper complexes with Curcumin (Cur) and 2,2’‐bipyridine‐5,5’‐dicarboxylic acid (BPYD) were synthesized and their cytotoxicity on the MDA‐MB‐231 cell lines was evaluated. The resulting complex was characterized using FTIR, UV/VIS, CHNS, TGA, ICP‐MS, and Mass spectroscopy techniques. The in‐vitro cytotoxicity was studied on the MDA‐MB‐231 as a cancerous cell line and the HUVEC as a normal cell line. Reactive oxygen species (ROS) production was measured using the 2′,7′‐dichlorofluorescein diacetate (DCFDA) test in the MDA‐MB‐231 cancer cell lines. The in‐vitro assays revealed that all synthesized copper complexes exhibited a higher cytotoxicity effect than carboplatin as a positive control on the MDA‐MB‐231 cells. While the synthesized complexes exhibited cytotoxic effects on cancerous cell lines, they are practically safe on normal cells. The Cu‐Cur‐BPYD complexes ( a5 & b5 ) exhibited higher cytotoxicity on MDA‐MB‐231 cells with IC 50 s around 4.9 and 2.3 mM, respectively. It can be concluded that the synthesized Cu‐Cur‐BPYD complexes ( a5 & b5 ) could be considered effective anticancer candidates in complementary studies.