Transcription activation in <i>Escherichia coli</i> and <i>Salmonella</i>
Stephen Busby, Douglas F. Browning
Abstract
ABSTRACT Promoter-specific activation of transcript initiation provides an important regulatory device in Escherichia coli and Salmonella . Here, we describe the different mechanisms that operate, focusing on how they have evolved to manage the “housekeeping” bacterial transcription machinery. Some mechanisms involve assisting the bacterial DNA-dependent RNA polymerase or replacing or remodeling one of its subunits. Others are directed to chromosomal DNA, improving promoter function, or relieving repression. We discuss how different activators work together at promoters and how the present complex network of transcription factors evolved.
Topics & Concepts
PromoterTranscription (linguistics)Escherichia coliRNA polymeraseBiologySalmonellaDNAGeneticsGeneral transcription factorCell biologyGeneGene expressionBacteriaLinguisticsPhilosophyBacterial Genetics and BiotechnologyRNA and protein synthesis mechanismsCRISPR and Genetic Engineering