Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy
Yuping Ning, Yi Cai, Youchao Dai, Fuxiang Li, Siwei Mo, Oliver Werz, Xinchun Chen
Abstract
inhibited mitochondrial fusion and subsequently reduced ATP production, which, in turn, severely impaired macrophages' mycobactericidal activity by inhibiting autophagy. Impairment of mycobactericidal activity and autophagy was replicated using oligomycin, an inhibitor of ATP synthase. In summary, our study revealed that MFN1-mediated mitochondrial fusion is essential for macrophages' mycobactericidal activity through the regulation of ATP-dependent autophagy. The MFN1-mediated metabolism pathway might be a target for the development of a host direct therapy (HDT) strategy against tuberculosis.
Topics & Concepts
MFN1AutophagyBiologymitochondrial fusionCell biologyMitochondrionMitochondrial fissionMFN2BiochemistryApoptosisMitochondrial DNAGeneAutophagy in Disease and TherapyMitochondrial Function and PathologyATP Synthase and ATPases Research