FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment
K. Patricia Hartmann, Merel van Gogh, Patrick C. Freitag, Florian Kast, Gabriela Nagy‐Davidescu, Lubor Borsig, Andreas Plückthun
Topics & Concepts
Tumor microenvironmentStromal cellCancer researchFibroblast activation protein, alphaIn vivoCancer-Associated FibroblastsGene deliveryStromaCancer cellBiologyTropismGenetic enhancementCancerImmunologyGeneImmunohistochemistryTumor cellsVirusBiochemistryGeneticsBiotechnologyPeptidase Inhibition and AnalysisVirus-based gene therapy researchUbiquitin and proteasome pathways