Bioengineered models of Parkinson’s disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
Nicholas J. Fiore, Yosif Ganat, Kapil Devkota, Rebecca Batorsky, Ming Lei, Kyongbum Lee, Lenore Cowen, Gist F. Croft, Scott Noggle, Thomas J.F. Nieland, David L. Kaplan
Topics & Concepts
DopaminergicParkinson's diseaseTranscriptomeInduced pluripotent stem cellNeuroscienceBiologyLRRK2Disease3D cell cultureDopamineComputational biologyCell cultureSystems biologyCellular modelScaffoldCell biologyGeneGene expressionMedicineGeneticsPathologyBiomedical engineeringEmbryonic stem cellPluripotent Stem Cells ResearchCRISPR and Genetic Engineering3D Printing in Biomedical Research