A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing
Samuel Ogbeide Ebhodaghe
Abstract
model and wound type, blood loss in treatment groups, biocompatibility and adhesive strength. Next, major outcomes on several techniques for improving the mechanical properties of gelatin biopolymer for wound healing are discussed. Then, effects of crosslinking on mechanical properties and hydrogel biocompatibility, in particular, the relationship between DHT crosslinking and gelation concentration are presented. Finally, research on adhesive anti-biofilm hydrogels are summarized, with focus on bacterial cellulosic, and chitosan - based hydrogels. Though similar reviews have been presented, the role of specific biological macromolecule-based composites such as chitosan and gelatin, have not been reviewed for some time despite the abundance of primary research findings. Knowledge gap and a list of unaddressed research questions are presented to aid further work in the field.