NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1
Zhiheng Zhang, Bojiao Song, Haowei Wei, Yang Liu, Wenjie Zhang, Yuhong Yang, Beicheng Sun, Beicheng Sun
Topics & Concepts
Cancer researchMHC class IImmunotherapyPancreatic cancerDownregulation and upregulationBiologyImmune checkpointCD8Gene knockdownMedicineCancerAntigenImmune systemImmunologyInternal medicineCell cultureGeneticsBiochemistryGeneMechanisms of cancer metastasisCancer Mechanisms and TherapyHippo pathway signaling and YAP/TAZ