The Relationship between Coronary Artery Disease and SIRT1 Protein
Lütfü Aşkın
Abstract
Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
Topics & Concepts
Coronary artery diseaseCardiologyInternal medicineMedicineDiseaseSirtuins and Resveratrol in MedicineBiochemical effects in animalsAutophagy in Disease and Therapy