Therapeutic and Prophylactic Effect of the Experimental Bacteriophage Treatment to Control Diarrhea Caused by <i>E. coli</i> in Newborn Calves
Mohammed Mijbas Mohammed Alomari, Marta Dec, Anna Nowaczek, Andrzej Puchalski, Andrzej Wernicki, C. Kowalski, Renata Urban‐Chmiel
Abstract
for 5 days. On the first day, the calves received the suppositories twice-in the morning and 12 h later; subsequently they were administered once a day. The health status of the calves was observed for 11 days after the first application of suppositories. A protective and preventive effect of the experimental therapy was obtained in the research. The probiotic-phage suppositories reduced the duration of diarrhea in calves, completely eliminating it within 24-48 h after use. The therapy stimulated the activation of immune mechanisms in calves, which translated into an enhanced specific and nonspecific response and increased resistance to infection.