Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens
Mioko Kawaguchi, Masayuki Satake, Botao Zhang, Yue-Yun Xiao, Masayuki Fukuoka, Hajime Uchida, Hiroshi Nagai
Abstract
A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.
Topics & Concepts
Mass spectrometryDerivative (finance)ChemistryStereochemistryBiologyChromatographyFinancial economicsEconomicsMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisSynthetic Organic Chemistry Methods