The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma
Michael Heider, Ruth Eichner, Jacob Stroh, Volker Morath, Anna Kuisl, Jana Zecha, Jannis Lawatscheck, Kheewoong Baek, Anne-Kathrin Garz, Martina Rudelius, Friedrich‐Christian Deuschle, Ulrich Keller, Simone Lemeer, Mareike Verbeek, Katharina S. Götze, Arne Skerra, Wolfgang Weber, Johannes Büchner, Brenda A. Schulman, Bernhard Küster, Vanesa Fernández‐Sáiz, Florian Bassermann
Topics & Concepts
CereblonTransmembrane proteinHsp90BiologyCell biologyTransmembrane domainBiogenesisMembrane proteinChaperone (clinical)Function (biology)Computational biologyBiochemistryAmino acidMembraneHeat shock proteinReceptorUbiquitinPathologyMedicineUbiquitin ligaseGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways