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Human Lectins, Their Carbohydrate Affinities and Where to Find Them

Cláudia D. Raposo, André B. Canelas, M. Teresa Barros

2021Biomolecules75 citationsDOIOpen Access PDF

Abstract

Lectins are a class of proteins responsible for several biological roles such as cell-cell interactions, signaling pathways, and several innate immune responses against pathogens. Since lectins are able to bind to carbohydrates, they can be a viable target for targeted drug delivery systems. In fact, several lectins were approved by Food and Drug Administration for that purpose. Information about specific carbohydrate recognition by lectin receptors was gathered herein, plus the specific organs where those lectins can be found within the human body.

Topics & Concepts

LectinReceptorCarbohydrateAffinitiesBiologyInnate immune systemC-type lectinImmune systemBiochemistryCellFicolinTargeted drug deliveryComputational biologySignal transductionCell biologyDrugImmunologyPharmacologyGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchInvertebrate Immune Response Mechanisms