CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae
Dongjie Chen, Yunan Zhao, Yanqin Qiu, Liying Xiao, Huaqiang He, Dongmei Zheng, Xiaoqin Li, Xiaoli Yu, Nengluan Xu, Xinlan Hu, Falin Chen, Hongru Li, Yusheng Chen
Abstract
BACKGROUND: (KP), is a serious public health concern. However, the underlying mechanism of tigecycline resistance is unclear. In this study, we evaluated the role of the CusS-CusR two-component system (TCS), which is associated with copper/silver resistance, in tigecycline resistance in CRKP. METHODS: was deleted and complemented by the suicide vector pKO3-Km plasmid and pGEM-T-easy plasmid, respectively. RESULTS: , correspondingly decreased and increased significantly. CONCLUSION: In addition to its primary function in resistance to copper/silver, the CusS-CusR two-component system is associated with CRKP resistance to tigecycline.