Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids
С. Н. Адамович, E. Kh. Sadykov, Igor А. Ushakov, Е. Н. Оборина, Lydmila A. Belovezhets
Abstract
Silatrane-1H-pyrrole-2-carboxamide hybrids conjugated via propane-1,3-diyl linker have been synthesized by the reaction of 1-(3-aminopropyl)silatrane with 2-(trichloroacetyl)pyrroles. Their in silico screening would predict their antitumor activity. Their in vitro screening for antimicrobial activity revealed the representative with R1 = R2 = R3 = H to be the most potent against Gram-positive microorganisms such as E. durans, B. subtilis and E. coli.
Topics & Concepts
ChemistryAntimicrobialPyrroleCarboxamideAntibacterial activityLinkerConjugated systemPropaneIn vitroCombinatorial chemistryHybridIn silicoStereochemistryBacteriaOrganic chemistryBiochemistryGenePolymerBotanyGeneticsBiologyOperating systemComputer sciencePorphyrin and Phthalocyanine ChemistryCancer therapeutics and mechanismsClick Chemistry and Applications